Anti-Mouse PD-L1/B7-H1 Antibody
$103.00 – $387.00
Anti-Mouse PD-L1/B7-H1 Antibody. Detects mouse PD-L1/B7-H1 (CD274) in immunofluorescence, western blot. Knockout-validated. Recombinant monoclonal rat IgG.
|Blocking, ELISA, FC, IHC|
|Rat IgG2b, κ|
|Formulation||PBS, pH 6.5|
|store undiluted at 4oC, do not freeze|
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Figure 1. Immunofluorescence of FFPE mouse tissues. Salivary gland (left) and liver (middle, right) tissue representative PD-L1 stains (red, anti-rat IgG Alexa-594) are shown for BALB/c mouse with DAPI nuclear stain.
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