GAL4-DBD-PPARα-LBD-BSD

The Peroxisome Proliferator-Activated Receptor Alpha (PPARα) is a member of the nuclear receptor (NR) subfamily 1, group C, member 1 (NR1C1) and is encoded by the PPARA gene.

Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-activated transcription factors within the nuclear hormone receptor superfamily, comprising three subtypes: PPARα, PPARγ, and PPARβ/δ. Activation of PPARα reduces triglyceride levels and regulates energy homeostasis, while PPARγ enhances insulin sensitivity and PPARβ/δ promotes fatty acid oxidation and energy expenditure. Collectively, PPARs play a pivotal role in maintaining metabolic function and energy balance.

Researchers often study PPARα to understand its involvement in conditions such as dyslipidemia, fatty liver disease, and cardiovascular health.

The GAL4-DBD-PPARα-LBD-BSD fusion construct provides a robust system to investigate ligand interactions with PPARα using the GAL4-UAS reporter system. Supplied as high-titer lentiviral particles with flexible readout options (GFP, RFP, or Firefly Luciferase), this product allows researchers to establish their own cell lines, eliminating the need for repeated transfections—resulting in significant cost savings over time while ensuring reliable, reproducible results. For custom solutions featuring alternative nuclear receptor family members, we offer similar pricing and a streamlined production timeline.

Contact us today to see how this tool can accelerate your drug discovery pipeline and therapeutic research.