GAL4-DBD-PPARδ-LBD-BSD

Peroxisome Proliferator-Activated Receptors (PPARs) are a group of ligand-activated transcription factors within the nuclear hormone receptor superfamily, including PPARα, PPARγ, and PPARβ/δ. Each subtype plays a unique role in energy regulation and metabolic processes. Activation of PPARα helps regulate lipid homeostasis, PPARγ enhances glucose metabolism, and PPARβ/δ stimulates fatty acid oxidation, promoting energy expenditure.

Peroxisome Proliferator-Activated Receptor Delta (PPARδ), also known as PPARβ, is a member of the nuclear receptor (NR) subfamily 1, group C, member 2 (NR1C2), encoded by the PPARD gene. PPARδ is highly expressed in various tissues, such as muscle, liver, and heart, and is integral to muscle physiology, lipid metabolism, and inflammation regulation. Its role in enhancing energy efficiency makes it a key focus in studies related to metabolic diseases and exercise physiology.

The GAL4-DBD-PPARδ-LBD-BSD fusion construct is specifically designed to assess ligand interactions with PPARδ using the GAL4-UAS reporter system. Supplied as high-titer lentiviral particles with flexible readout options (GFP, RFP, or Firefly Luciferase), this product enables researchers to create stable cell lines, eliminating the need for transient transfections—offering significant cost savings while ensuring consistency and reliability in experimental outcomes. For custom solutions featuring alternative nuclear receptor family members, we offer similar pricing and a streamlined production timeline.

Contact us today to see how this tool can accelerate your drug discovery pipeline and therapeutic research.