GAL4-DBD-RXRα-LBD-BSD

Retinoid X Receptor Alpha (RXRα) is a versatile receptor encoded by the RXRA gene, categorized under nuclear receptor subfamily 2, group B, member 1 (NR2B1). RXRα functions primarily as a heterodimeric partner, crucial for modulating pathways in cellular differentiation, lipid metabolism, and immune function. Ligand binding, such as 9-cis-retinoic acid, activates RXRα, facilitating its role in gene transcription and metabolic homeostasis.

Retinoid X Receptors (RXRs) are key members of the nuclear retinoid receptor family, comprising RXR-α, RXR-β, and RXR-γ. These receptors play essential roles in cellular processes such as lipid and glucose metabolism. Each RXR subtype, encoded by unique genes, undergoes alternative splicing, resulting in various protein isoforms. RXRs can form homodimers or heterodimers with other nuclear receptors, including RARs, PPARs, and vitamin D receptors, amplifying their regulatory impact on gene expression.

The GAL4-DBD-RXRα LBD fusion construct is specifically designed to monitor RXRα activity. Supplied as high-titer lentiviral particles with flexible readout options (GFP, RFP, or Firefly Luciferase), this product allows researchers to establish their own cell lines, reducing the need for repeated transfections—resulting in significant cost savings and ensuring consistent results. For custom solutions featuring alternative nuclear receptor family members, we offer similar pricing and a streamlined production timeline.

Contact us today to see how this tool can accelerate your drug discovery pipeline and therapeutic research.