GAL4-DBD-THRA-LBD-BSD

Thyroid Hormone Receptors (THRs) consist of alpha and beta subtypes, critical members of the nuclear receptor family that mediate thyroid hormone activity. These receptors regulate diverse physiological processes, including growth, metabolic function, and cardiac rhythm. THRα and THRβ are encoded by separate genes, NR1A1 (THRA) and NR1A2 (THRB), producing isoforms via differential splicing or promoter usage.

Thyroid Hormone Receptor Alpha (THRα), encoded by the THRA gene, plays a significant role in cardiac rhythm and development, with its expression predominantly in the heart and other tissues involved in metabolic regulation. THRα binds thyroid response elements (TREs) in DNA, and upon T3 hormone binding, undergoes conformational changes, dissociating corepressors and recruiting coactivators to facilitate gene transcription.

The GAL4-DBD-THRα LBD fusion construct is specifically designed for studying ligand interactions with THRα, supplied as high-titer lentiviral particles with readout options like GFP, RFP, or Firefly Luciferase. This design allows researchers to generate their own cell lines, eliminating repeated transfections for cost-effective, reproducible results. For custom solutions featuring alternative nuclear receptor family members, we offer similar pricing and a streamlined production timeline.

Contact us today to see how this tool can accelerate your drug discovery pipeline and therapeutic research.