GAL4-DBD-ERα-LBD-BSD

Estrogen Receptor Alpha (ERα, NR3A1), encoded by the ESR1 gene, is a member of the Estrogen Receptor family, which consists of intracellular ERα and ERβ. Activation of intracellular ERs, such as by 17β-estradiol, triggers their translocation to the nucleus where they regulate gene transcription, playing key roles in growth, metabolism, and reproductive health. ERα signaling is also implicated in the development and progression of certain cancers, making it a significant target in both fundamental and clinical research.

The GAL4-DBD-ERα-LBD-BSD fusion construct provides a reliable system to study ligand interactions with ERα through the GAL4-UAS reporter system. Supplied as high-titer lentiviral particles with flexible readout options (GFP, RFP, or Firefly Luciferase), this construct allows researchers to develop stable cell lines, negating the need for repeated transfections—yielding substantial cost savings and consistent experimental data. For custom solutions featuring alternative nuclear receptor family members, we offer similar pricing and a streamlined production timeline.

Contact us today to see how this tool can accelerate your drug discovery pipeline and therapeutic research.