HSPC/Chol/DSPE-mPEG2000/MPL (56.2/38.5/4.3/1, mol/mol) Liposomes

HSPC/Chol/DSPE-mPEG2000/MPL (56.2/38.5/4.3/1, mol/mol) Liposomes

SKU: AL-0001

Price range: $750.00 through $2,350.00

PEGylated, with MPL Adjuvant

Immunogenic PEGylated liposomes containing 1 mol% of the Toll-like receptor 4 (TLR4) agonist monophosphoryl lipid A (MPL), which is effective as an immune-stimulating adjuvant. This product is particularly useful in preclinical applications including vaccination, immunotherapy, or other areas of immunology research, especially in situations where a immunologically-active agent is meant to be administered for the purpose of stimulating an immune response. The liposome vehicle is very similar to that of the well-characterized Doxil® formulation in terms of lipid composition, which is desirable for translational purposes.

 

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Specifications

AL-0001
Lipid Composition HSPC/Chol/DSPE-mPEG2000/MPL (56.2/38.5/4.3/1, mol/mol)
30 mM
Hydration Solution PBS, pH 7.4
External Solution PBS, pH 7.4
Average Size 70-120 nm
We synthesize custom liposomes like this. Contact us today to request a custom formulation.

Additional Information

Additional Information

Liquid, suspension
2 °C to 8 °C (do not freeze)
Shelf Life* 6 months
HSPC: L-α-phosphatidylcholine, hydrogenated (Soy); Chol : Cholesterol; DSPE-mPEG2000: 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]; MPL: monophosphoryl lipid A from Salmonella enterica serotype minnesota Re 595 (Re mutant)
Applications
Background
References [1] https://www.sigmaaldrich.com/catalog/product/sigma/l6895?lang=en&region=US

*When maintained under the specified storage conditions.