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Gilteritinib (ASP2215) Liposomes
$995.00 – $4,095.00
AZD1208 Liposomes, Formulation RB4T4
$1,295.00 – $1,995.00
PEGylated liposomes containing AZD1208. AZD1208 is a potent Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. AZD1208 induces autophagy, cell cycle arrest and apoptosis. This product is a pre-formulated liposomal version of AZD1208 which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
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Product Data:
Figure 1 (Thumbnail). Solubilization of AZD1208 by liposomes. Free (left) and liposomal (right) forms of AZD1208 are shown under the microscope at matched concentrations (5 mg/mL) in the same buffer solution. To observe the incompatibility of free AZD1208 in aqueous media, AZD1208 was first dissolved in DMSO, then diluted in 292 mM sucrose solution, and further diluted in DPBS (1X) to match the concentration of liposomal AZD1208.
Details
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DLL-0023 |
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PEGylated liposomes loaded with AZD1208 |
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| Formulation No. | RB4T4 |
| Concentration Total Lipid | 30 mM |
| Concentration AZD1208 | 5.0 mg/mL (± ~5%) |
| Hydration Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| External Solution | 116.8 mM sucrose, 82.7 mM NaCl, 4.9 mM Na2HPO4, 0.9 mM KH2PO4, 1.6 mM KCl |
| Liposome Avg. Size | 70-120 nm |
Bioactive Compound Details
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| Encapsulated Compound | AZD1208 |
| Alias(es) | |
| CAS No. | 1204144-28-4 |
| Target(s) | Pim kinase (pan) |
| Signaling Pathway |
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Additional Information
Additional Information
| Liquid, suspension | |
| 2 °C to 8 °C (do not freeze), protect from light | |
| Shelf Life* | At least 1 month |
| Applications | |
| Background | |
| References |
*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.