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Liposomal Formulation Development
We provide a wide range of nano formulation services for preclinical research. Our specialties include liposomes, lipid nanoparticles (LNPs), solid lipid nanoparticles (SLNs), micelles, and polymeric nanoparticles among numerous other drug delivery platforms. Our expert staff consists of well-trained formulation scientists with diverse backgrounds in all fields of nanomedicine. We routinely help our clients encapsulate mRNA, small molecules, peptides, proteins, and other bioactive molecules into appropriate nanocarriers. Whether you are an academic researcher, government employee, or a scientist working at a pharmaceutical or biotechnology company, we are focused on providing the formulation service that works best for you. Contact us today and let our experts tackle your project with the dedication and accuracy you deserve.
Service Guide
The guide below can help you decide which type of liposome service you would like. If you’re not sure which is best for your application, use the form to contact us and our staff will help you. Most of our customers ask for encapsulation of their active and surface modification with an antibody. Some examples of the different types of liposome formulation development services and other nano formulation development services we routinely perform are listed below.
All products and services for research use only. We do not sell to patients.
Liposomes and Lipid Nanoparticles (LNPs)
– Solid Lipid Nanoparticles (SLNs)
– Encapsulation of siRNA
– Formulations for gene delivery, gene editing, CRISPR/Cas9, etc.
– Functionalized LNPs (protein, peptide, aptamer, etc.)
– Liposomes, micelles, or polymeric nanoparticles encapsulating small molecules
– Encapsulation of water-insoluble drugs
– Remote-loading and metal ion complex liposomes
– Antibody and protein conjugation to liposome/LNP surface
– Conjugation with peptides, aptamers, folate, and other targeting moieties
– Fluorescent liposomes for flow cytometry, custom-made to various size specifications, many fluorophores available
– Fluorescent liposomes for in vivo imaging/biodistribution studies and visualizing in vivo tumor targeting (EPR effect)
– Encapsulation of more than one bioactive small molecule at pre-defined ratios (i.e. ratiometric dosing, combination index, synergy studies)
– Co-formulation with adjuvants for vaccine development or immunogenic liposomes, solutions for peptide antigen delivery
Service Options
Formulation Development services can range from simple preparation to fully validated and characterized. View our analytical capabilities and characterization services, or contact us for more information.
Figure 1. Lipid Nanoparticles (LNPs) with Encapsulated EGFP mRNA Left. DLS profile of LNPs with encapsulated EGFP mRNA. Right. Fluorescence microscopy of EGFP protein expression in HEK293 cells treated with EGFP mRNA LNPs (24 h).
Figure 2. Liposomal formulation development example. Left. Enhanced solubility of a customers small molecule drug depicted in microscopy images, comparing free vs liposomal forms at 3.1 mg/mL of the compound in PBS. Right. Dynamic light scattering (DLS) snapshot for the drug loaded liposomes, avg. size =~100 nm.
How To Get Started
Use the contact form to tell us a little about your project and what you want to accomplish. We’ll reply by email to collect more information specific to your project that will help us to generate a quote for you.
Analytical Capabilities
- Particle size and polydispersity (DLS)
- Zeta potential (Capillary electrophoresis)
- Encapsulation Efficiency (SEC/HPLC)
- Release-over-time assays
- Antibody/protein conjugations (SDS-PAGE)
- Stability analysis
- Cytotoxicity assays (in vitro)
Note: All products and services are for preclinical research only, not intended for human consumption or veterinary purposes.
Liposome Products
Browse our catalog of preformed liposomes.
