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SP600125 Liposomes, Formulation HZ12
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Gilteritinib (ASP2215) Liposomes
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Rocaglamide Liposomes, Formulation KHE9A
$1,295.00 – $3,295.00
PEGylated liposomes containing Rocaglamide (Roc-A). Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective HSF1 activation inhibitor (IC50 ~50 nM). Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also exhibits anti-leukemia activity. Rocaglamide is insoluble in aqueous media. This product is a pre-formulated liposomal version of Rocaglamide which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
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Product Data:
Figure 1 (Thumbnail). Solubilization of Rocaglamide (Roc-A) by liposomes. Rocaglamide is shown under magnification in free or liposomal forms at 4.0 mg/mL. Left: Rocaglamide is insoluble in aqueous media. Rocaglamide was dissolved in DMSO and diluted in 322 Buffer (292 mM sucrose, 0.5% DPBS) to examine aqueous solubility. Right: Matched concentration of Rocaglamide is shown in liposomal form (formulation KHE9A) in the same bulk solution.
Details
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DLL-0019 |
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PEGylated liposomes loaded with Rocaglamide (Roc-A) |
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| Formulation No. | KHE9A |
| Concentration Total Lipid | 60 mM |
| Concentration Rocaglamide | 4.0 mg/mL (± ~5%) |
| Hydration Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| External Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| Liposome Avg. Size | 70-120 nm |
Bioactive Compound Details
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| Encapsulated Compound | Rocaglamide |
| Alias(es) | Roc-A |
| CAS No. | 84573-16-0 |
| Target(s) | NFκB, HSF1, eIF4A |
| Signaling Pathway | NFκB pathway, heat shock response |
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Additional Information
Additional Information
| Liquid, suspension | |
| 2 °C to 8 °C (do not freeze), protect from light | |
| Shelf Life* | At least 1 month |
| Applications | |
| Background | |
| References |
*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.