Lificiguat (YC-1) Liposomes, Formulation FNT8P.2
$2,995.00
PEGylated liposomes containing HIF-1α inhibitor Lificiguat (YC-1). Lificiguat (YC-1) is an inhibitor of Hypoxia-inducible factor-1 alpha (HIF-1 alpha). YC-1 also activates soluble guanylyl cyclase (sGC) in (NO)-independent manner. Lificiguat (YC-1) is insoluble in aqueous media. This product is a pre-formulated liposomal version of Lificiguat which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
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Product Data:
Figure 1 (Thumbnail). Solubilization of Lificiguat (YC-1) by liposomes. Lificiguat is shown under magnification in free or liposomal forms at 2.5 mg/mL. Left: Lificiguat is insoluble in aqueous media. Lificiguat was dissolved in DMSO and diluted in 322 Buffer (292 mM sucrose, 0.5% DPBS) to examine aqueous solubility. Right: Matched concentration of Lificiguat is shown in liposomal form (formulation FNT8P.2) in the same bulk solution.
Figure 2. DLS analysis of Lificiguat Liposomes, Formulation FNT8P.2 (batch 13270). The average size and PDI of triplicate measurements are annotated on the representative snapshot from DLS data acquisition screen. The data are representative of a typical batch.
Details
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DLL-0016 |
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PEGylated liposomes loaded with Lificiguat (YC-1) |
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Formulation No. | FNT8P.2 |
Concentration Total Lipid | 60 mM |
Concentration Cefixime | 2.5 mg/mL |
Hydration Solution | 292 mM sucrose, 0.5% DPBS (1X) |
External Solution | 292 mM sucrose, 0.5% DPBS (1X) |
Liposome Avg. Size | 70-120 nm |
Bioactive Compound Details
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Encapsulated Compound | Lificiguat |
Alias(es) | YC-1 |
CAS No. | 170632-47-0 |
Target(s) | cGC, HIF-1α |
Signaling Pathway | Hypoxia/HIF pathway |
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Additional Information
Additional Information
Liquid, suspension | |
2 °C to 8 °C (do not freeze), protect from light | |
Shelf Life* | At least 1 month |
Applications | |
Background | |
References |
*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.