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A939572 Liposomes
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Eganelisib (IPI-549) Liposomes, Formulation WNX5.2
$2,995.00
PEGylated liposomes containing PI3Kγ inhibitor Eganelisib (IPI-549). Eganelisib (IPI-549) is a potent and selective PI3Kγ inhibitor (IC50 16 nM) which is reported to exhibit more than 100-fold selectivity over other lipid and protein kinases and potentiate immunotherapy with immune checkpoint inhibitors in mice. IPI-549 is insoluble in aqueous media. This product is a pre-formulated liposomal version of IPI-549 which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
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Product Data:
Figure 1 (Thumbnail). Solubilization of Eganelisib (IPI-549) by liposomes. Eganelisib is shown under magnification in free or liposomal forms at 2.0 mg/mL. Left: Eganelisib is insoluble in aqueous media. Eganelisib was dissolved in DMSO and diluted in 322 Buffer (292 mM sucrose, 0.5% DPBS) to examine aqueous solubility. Right: Matched concentration of Eganelisib is shown in liposomal form (formulation WNX5.2) in the same bulk solution.
Figure 2. DLS analysis of Eganelisib (IPI-549) Liposomes, Formulation WNX5.2 (batch 93263). The average size and PDI of triplicate measurements are annotated on the representative snapshot from DLS data acquisition screen. The data are representative of a typical batch.
Details
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DLL-0015 |
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PEGylated liposomes loaded with Eganelisib (IPI-549) |
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| Formulation No. | WNX5.2 |
| Concentration Total Lipid | 60 mM |
| Concentration Eganelisib | 2.0 mg/mL |
| Hydration Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| External Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| Liposome Avg. Size | 70-120 nm |
Bioactive Compound Details
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| Encapsulated Compound | Eganelisib |
| Alias(es) | IPI-549 |
| CAS No. | 1693758-51-8 |
| Target | PI3Kγ |
| Signaling Pathway | PI3K |
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Additional Information
Additional Information
| Liquid, suspension | |
| 2 °C to 8 °C (do not freeze), protect from light | |
| Shelf Life* | At least 1 month |
| Applications | |
| Background | |
| References |
*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.