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Home Liposome Products Drug Loaded Liposomes Tanespimycin (17-AAG) Liposomes, Formulation XT28.1
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Comparison of Tanespimycin (17-AAG) aqueous solubility in free or liposomal forms at 2.5 mg/mL, shown at 10x and 4x magnification

Tanespimycin (17-AAG) Liposomes, Formulation XT28.1

SKU: DLL-0011

$995.00 – $2,995.00

PEGylated liposomes containing Hsp90 inhibitor Tanespimycin (17-AAG). Tanespimycin exhibits 100-fold higher binding affinity to HSP90 derived from tumor cells vs normal cells, and induces apoptosis, necrosis, autophagy, and mitophagy. Tanespimycin is insoluble in aqueous media. This product is a pre-formulated liposomal version of Tanespimycin which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.

We synthesize custom liposomes like this. To see a full list of our formulation capabilities, click here.

Categories: Liposome Products, Drug Loaded Liposomes Tags: 17-AAG, Heat shock response, Hsp90, Tanespimycin

Available Options:

  • Specifications
  • Additional Information

Specifications

Product Data:

Figure 1 (Thumbnail).  Enhancement of solubility for tanespimycin is shown in the representative images. Tanespimycin is insoluble in aqueous media at the specified concentration (2.5 mg/mL). Matched concentration of tanespimycin liposomes is shown.

 

Figure 2. DLS analysis of Tanespimycin Liposomes, Formulation XT28.1 (batch 65234). The average size and PDI of triplicate measurements are annotated on the representative snapshot from DLS data acquisition screen. The data are representative of a typical batch.

 

 

 

 

 

DLL-0011

Encapsulated Compound Tanespimycin
Alias(es) 17-AAG; CP127374; NSC-330507; KOS 953
Target Hsp90
Activity Inhibitor
Signaling Pathway Heat shock response (HSR) pathway
XT28.1
2.5 mg/mL
60 mM
Hydration Solution 300 mM sucrose
External Solution 300 mM sucrose
Average Size 70-120 nm
We synthesize custom liposomes like this. Contact us today to request a custom formulation.

Additional Information

Additional Information

Liquid, suspension
2 °C to 8 °C (do not freeze), protect from light
Shelf Life* At least 1 month
Applications
Background
References

*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.

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