Nexturastat A Liposomes

SKU: DLL-0012

$595.00 – $1,195.00

PEGylated liposomes containing Nexturastat A. Nexturastat A is a potent and selective HDAC6 inhibitor (IC50: 5 nM), with >190-fold selectivity over other HDACs. This product is a pre-formulated liposomal version of Nexturastat A which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.

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Specifications

Product Data:

Figure 1 (Thumbnail).  Solubilization of Nexturastat A by liposomes. Nexturastat A is shown under magnification in free or liposomal forms at 2.5 mg/mL. Left: Ixabepilone is insoluble in aqueous media (pH ~6.5). Nexturastat A was dissolved in DMSO and diluted in 322 Buffer (292 mM sucrose, 0.5% DPBS) to examine aqueous solubility. Right: Matched concentration of Nexturastat A is shown in liposomal form (formulation NA-60A) in the same bulk solution and pH.

 

Figure 2. DLS analysis of Nexturastat A Liposomes, Formulation NA-60A (batch 04531). The average size and PDI of triplicate measurements are annotated on the representative snapshot from DLS data acquisition screen. The data are representative of a typical batch.

 

 

 

 

 

 

Details

 

 

DLL-0012

PEGylated liposomes loaded with Nexturastat A
Formulation No. NA-60A
Concentration Total Lipid 60 mM
Concentration Nexturastat A 2.5 mg/mL (± ~5%)
Hydration Solution 292 mM sucrose, 0.5% DPBS (1X)
External Solution 292 mM sucrose, 0.5% DPBS (1X)
Liposome Avg. Size 70-120 nm
 

Bioactive Compound Details

 
Encapsulated Compound Nexturastat A
Alias(es) Nexturastata; s7473; nexturastat-a; 4-((1-butyl-3-phenylureido)methyl)-N-hydroxybenzamide;
CAS No. 1403783-31-2
Target(s)  HDAC6
Signaling Pathway Epigenetics/HDAC

 

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Additional Information

Additional Information

Liquid, suspension
2 °C to 8 °C (do not freeze), protect from light
Shelf Life* At least 1 month
Applications
Background
References

*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.