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Nexturastat A Liposomes
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A939572 Liposomes
$2,995.00
PEGylated liposomes containing SCD1 inhibitor A939572. A939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor with reported IC50s of <4 nM and 37 nM for mouse and human SCD1, respectively. A939572 is insoluble in aqueous media. This product is a pre-formulated liposomal version of A939572 which is supplied ready to use in vitro or in vivo. The liposomes are PEGylated for optimal in vivo performance. For preclinical research use only.
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Specifications
Product Data:
Figure 1 (Thumbnail). Solubilization of A939572 by liposomes. A939572 is shown under magnification in free or liposomal forms at 500 mcg/mL. Left: A939572 is insoluble in aqueous media. A939572is was dissolved in DMSO and diluted in 322 Buffer (292 mM sucrose, 0.5% DPBS) to examine aqueous solubility. Right: Matched concentration of A939572is is shown in liposomal form (formulation A2D) in the same bulk solution.
Figure 2. DLS analysis of A939572 Liposomes, Formulation A2D (batch 78301). The average size and PDI of triplicate measurements are annotated on the representative snapshot from DLS data acquisition screen. The data are representative of a typical batch.
Details
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DLL-0013 |
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PEGylated liposomes loaded with A939572 |
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| Formulation No. | A2D |
| Concentration Total Lipid | 60 mM |
| Concentration A939572 | 500 mcg/mL |
| Hydration Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| External Solution | 292 mM sucrose, 0.5% DPBS (1X) |
| Liposome Avg. Size | 70-120 nm |
Bioactive Compound Details
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| Encapsulated Compound | A939572 |
| Alias(es) | |
| CAS No. | 1032229-33-6 |
| Target | SCD1 |
| Signaling Pathway | Lipogenesis pathway |
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Additional Information
Additional Information
| Liquid, suspension | |
| 2 °C to 8 °C (do not freeze), protect from light | |
| Shelf Life* | At least 1 month |
| Applications | |
| Background | |
| References |
*Product is too new for long-term stability data. This section will be updated regularly as new data becomes available.