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Home Gene Products Lentiviral Particles (All) Human LCN2 shRNA Lentivirus
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Human LCN2 shRNA Lentivirus

Human LCN2 shRNA Lentivirus

SKU: LSV-0013

$595.00 – $1,195.00

Validated LCN2 shRNA Lentivirus: High-titer shRNA lentiviral particles specific for human Lipocalin-2 (LCN2). The shRNA has been validated to meet or exceed 70% LCN2 knockdown efficiency using a specific fluorescence-based method that is more rapid and reliable than qPCR. The shRNA lentivirus is ultra-purified and concentrated to high-titer by PEG precipitation and sucrose gradient centrifugation, and ideal for transducing difficult-to-transfect cells including thawed and/or primary cells. Order a shRNA lentivirus set and receive lentivirus produced from mix of 2 independent shRNAs validated to knockdown the target gene (>70%) plus control lentivirus produced from mix of 2 scrambled shRNA constructs.

Have questions about this product? Need stable cell line instead? Send us a form and we’ll reply the same day: Contact Us 

Categories: Lentiviral Particles (All), Validated shRNA Lentivirus

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  • Specifications
  • Additional Information

Specifications

Key Advantages:

  • Same Cost For Custom Lentivirus – You can receive any combination of reporter (GFP/RFP/Luc/None) and selection marker (puromycin/blasticidin) for this product, without additional cost, by contacting us. To view our complete list of shRNA vectors, click here.
  • Superior knockdown – LipExoGen Validated shRNA Lentiviruses are produced using the third generation system and feature novel, optimized shRNA vectors which express a 19-20 bp shRNA, fluorescent (GFP or RFP) or luminescent (luciferase) reporter, and drug-selection marker (puromycin or blasticidin). Taking advantage of a proprietary prediction algorithm developed in-house, validated shRNA constructs are capable of delivering 70% or more knockdown efficiency with less off-target effects compared to longer or mixed-sequence shRNA/siRNAs.
  • Superior validation – All of our pre-made shRNA constructs are validated in-house using a specific fluorescence-based method that is more reliable than traditional qPCR. The validation process leverages bicistronic expression of the target mRNA and fluorescent reporter to confirm the efficacy of the shRNA. As knockdown validation can be readout using basic fluorescence microscopy, this low-cost, streamlined approach allows us to provide a superior-quality product at a price comparable or less than the average competitor.
  • Superior accuracy – Polyclonal shRNA-transduced stable cells can be established within 10 days and used for downstream applications while preserving more properties of the parental cells. In this way, high-efficiency knockdown from our validated shRNA lentiviral particles can be advantageous over sgRNA CRISPR-Cas9 systems which select for single cell clones.
  • Easily identify transduced cells – Validated shRNA constructs contain both fluorescent reporter and drug selection marker, allowing the flexibility to select transduced cells by puromycin/blasticidin or FACS sorting of GFP/RFP. Luciferase reporters are also available for detecting transduced cells in vitro or in vivo using luminescence-based techniques.

Product Data

Construct validation for human LCN2 shRNA Lentivirus

 

Figure 1. Knockdown validation for hLCN2-sh5-GFP-Puro.   HEK293FT cells were co-transfected with human LCN2-RFP bicistronic expression plasmid (red) and plasmids for the indicated shRNAs (GFP, green). After 24-36 hours, fluorescent images of the living cells were acquired by fluorescence microscopy. GFP represents transfection of the shRNA construct, whereas RFP indicates translation of the target mRNA. Higher knockdown efficiencies may be possible in stably-transfected cells. Sr-sh, scrambled shRNA.

 

 

 

 

 

 


Details

LSV-0013
 LCN2
lipocalin 2
NM_005564
Human

 


Recommended Control

Scrambled shRNA Control Lentivirus (mixture of two independent shRNAs), LSV-0024


Related Products

Mouse Lcn2 shRNA Lentivirus, LSV-0022

 


Custom Orders

If you require a modification to one of our products (for example, change in reporter or other vector component), please request a custom order. We provide a variety of fast and efficient services for the production of high-quality, custom lentiviral particles on demand, usually for the same or comparable price as the listed item.

Or, send us your cells and we will establish a stable shRNA cell line for you using this product. Learn more.

The cDNA lentivirus corresponding to this product is also available upon request, comparable price.

I want to:

Go to the custom shRNA lentiviral particles request form

View all custom lentiviral particle services

Additional Information

Additional Information

LCN2
lipocalin 2
n NM_005564
Homo sapiens
Alias Lipocalin 2; Neutrophil Gelatinase-Associated Lipocalin; Oncogene 24p3; 25 KDa Alpha-2-Microglobulin-Related Subunit Of MMP-9; Siderocalin; NGAL; P25; Migration-Stimulating Factor Inhibitor; Lipocalin 2 (Oncogene 24p3); Siderocalin LCN2; Lipocalin-2; 24p3; MSFI; HNL
Annotation Page https://www.ncbi.nlm.nih.gov/gene/?term=NM_005564
Gene IDs HGNC:HGNC:6526 Ensembl:ENSG00000148346 MIM:600181
Entrez Gene Summary “This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]“

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